Second General Meeting 14th - 16th July (virtual)
The Second General Meeting of Adher´n Rise was held virtually from July 14th - 16th due to the ongoing Covid-19 pandemics.
Achievements
The Action was successfully launched November 14th 2019 in Brussels at our kick-off meeting. In an exciting, motivating and highly interactive meeting the Management Committee, then consisting of 21 countries, met for the first time to establish the organisational structures of this network and to set the plan for the upcoming Grant Period.
Publications
A guide to adhesion GPCR research.
Liebscher I, Cevheroğlu O, Hsiao CC, Maia AF, Schihada H, Scholz N, Soave M, Spiess K, Trajković K, Kosloff M, Prömel S.
FEBS J. 2021 Nov 2. Online ahead of print.
doi: 10.1111/febs.16258.
Mimicking extracellular matrix-mediated mechano-activation by antibodies to control signaling of the adhesion G protein-coupled receptor GPR126/ADGRG6.
Jakob Mitgau, Julius Franke, Camilla Schinner, Gabriele Stephan, Sandra Berndt, Dimitris G. Placantonakis, Hermann Kalwa, Volker Spindler, Caroline Wilde, Ines Liebscher.
doi: https://doi.org/10.1101/2021.09.13.460127
Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
David M Favara, Ines Liebscher, Ali Jazayeri, Madhulika Nambiar, Helen Sheldon, Alison H Banham, Adrian L Harris.
Sci Rep. 2021 Apr 23;11(1):8870.
doi: 10.1038/s41598-021-85408-x
Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling.
Joshua D Frenster, Gabriele Stephan, Niklas Ravn-Boess, Devin Bready, Jordan Wilcox, Bjoern Kieslich, Caroline Wilde, Norbert Sträter, Giselle R Wiggin, Ines Liebscher, Torsten Schöneberg, Dimitris G Placantonakis.
Biol Chem. Jan-Jun 2021;296:100798. Epub 2021 May 20.
doi: 10.1016/j.jbc.2021.100798.
Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes.
Frenster JD, Kader M, Kamen S, Sun J, Chiriboga L, Serrano J, Bready D, Golub D, Ravn-Boess N, Stephan G, Chi AS, Kurz SC, Jain R, Park CY, Fenyo D, Liebscher I, Schöneberg T, Wiggin G, Newman R, Barnes M, Dickson JK, MacNeil DJ, Huang X, Shohdy N, Snuderl M, Zagzag D, Placantonakis DG.
Neurooncol Adv. 2020 Apr 28;2(1):vdaa053.
doi: 10.1093/noajnl/vdaa053.
eCollection 2020 Jan-Dec
GPCRmd uncovers the dynamics of the 3D-GPCRome
Rodríguez-Espigares I; Mariona Torrens-Fontanals; Johanna K. S. Tiemann; David Aranda-García; Juan Manuel Ramírez-Anguita; Tomasz Maciej Stepniewski; Nathalie Worp; Alejandro Varela-Rial; Adrián Morales-Pastor; Brian Medel-Lacruz; Gáspár Pándy-Szekeres; Eduardo Mayol; Toni Giorgino; Jens Carlsson; Xavier Deupi; Slawomir Filipek; Marta Filizola; José Carlos Gómez-Tamayo; Angel Gonzalez; Hugo Gutiérrezde-Terán; Mireia Jiménez-Rosés; Willem Jespers; Jon Kapla; George Khelashvili; Peter Kolb; Dorota Latek; Maria Marti-Solano; Pierre Matricon; Minos-Timotheos Matsoukas; Przemyslaw Miszta; Mireia Olivella; Laura Perez-Benito; Davide Provasi; Santiago Ríos; Iván R. Torrecillas; Jessica Sallander; Agnieszka Sztyler; Silvana Vasile; Harel Weinstein; Ulrich Zachariae; Peter W. Hildebrand; Gianni De Fabritiis; Ferran Sanz; David E. Gloriam; Arnau Cordomi; Ramon Guixà-González; Jana Selent
Nature Methods 2020 Aug;17(8):777-787
DOI doi:10.1038/s41592-020-0884-y
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A.
Ann N Y Acad Sci. 2019 Nov;1456(1):5-25.
doi: 10.1111/nyas.14094.
Meetings
Training Schools
Structure-Function-Analyses of Adhesion GPCRs
Virtual Training School
2021-09-13 to 2021-09-14
Organizers: Laura Kilpatrick & Mark Soave (University of Nottingham, UK)
Trainers:
- Martin Gustavsson (KU, DK)
- Dimitry Veprintsev (UoN, UK)
- Eline Koers (UoN, UK)
- Gáspár Pándy-Szekeres (KU, DK)
- Jarkko Lackman (KU, DK)
- Albert Kooistra (KU, DK)
Animal models for Adhesion GPCR research
Virtual Training School
2020-10-05 to 2020-10-06
Organizer: Katarina Trajkovic (Mediterranean Institute for Life Sciences Split, HR)
Trainers:
- Jörg Hamann (Amsterdam University Medical Centers, Netherlands)
- Samantha Hughes (Hogeschool van Arnhem en Nijmegen, Netherlands)
- Hsi-Hsien Lin (Chang-Gung University College of Medicine, Taiwan)
- Kelly Monk (Oregon Health & Science University, USA)
Miscellaneous
Virtual Mobility Grant
2021-09-27 to 2021-10-31
Ligand screening network for aGPCR
Virtual Mobility Grant
2021-10-01 to 2021-10-31
Transfer of knowledge on the design and application of optical biosensors to study adhesion GPCR function
Virtual Mobility Grant
2021-09-27 - 2021-10-30
Accurate modeling of aGPCR using AlphaFold2
Virtual Mobility Grant
2021-09-27 to 2021-10-15
Library Screening of Potential Adhesion G Protein-Coupled Receptor (aGPCR) Ligands
Virtual Mobility Grant
2021-10-05 to 2021-10-31
Advancing the set up of an adhesion GPCR Technology Database - engaging and empowering the network
Virtual Mobility Grant
2021-10-15 to 2021-10-25
Exploring the effects of electronic cigarettes on the expression of adhesion GPCRs